Is Bone Morphogenetic Protein-2 as Effective as Alveolar Distraction Osteogenesis for Vertical Bone Regeneration?
نویسندگان
چکیده
منابع مشابه
Periosteal Distraction Osteogenesis: An Effective Method for Bone Regeneration
The treatment of bone defects is challenging and controversial. As a new technology, periosteal distraction osteogenesis (PDO) uses the osteogenicity of periosteum, which creates an artificial space between the bone surface and periosteum to generate new bone by gradually expanding the periosteum with no need for corticotomy. Using the newly formed bone of PDO to treat bone defects is effective...
متن کاملBone morphogenetic protein signaling in the murine distraction osteogenesis model.
A murine distraction osteogenesis model was standardized to allow analysis of the molecular pathways associated with postnatal de novo bone formation. The authors examined the presence and expression of Bone Morphogenetic Proteins (BMPs) -2, -3, -4, -6 and -7, and the BMP receptors Alk3 and Alk6 at different stages. Strong signals were detected for BMP-4 at the end of the distraction period and...
متن کاملRecombinant human bone morphogenetic protein-2 suspended in fibrin glue enhances bone formation during distraction osteogenesis in rabbits
INTRODUCTION Bone morphogenetic protein-2 (BMP-2) has high potential for bone formation, but its in vivo effects are unpredictable due to the short life time. This study was designed to evaluate the effects of recombinant human (rh) BMP-2 suspended in fibrin on bone formation during distraction osteogenesis (DO) in rabbits. MATERIAL AND METHODS The in vitro release kinetics of rhBMP-2 suspend...
متن کاملAccelerators of Osteogenesis by Recombinant Human Bone Morphogenetic Protein-2
Bone morphogenetic protein (BMP) appears to be one of the most promising cytokine and for clinical use in reconstructive surgery for bony defects and augmentation. To evaluate the effect of basic fibroblast growth factor (bFGF), FK506, elcatonin, and hyperbaric oxygenation (HBO) on osteoinduction by recombinant human bone morphogenetic protein-2 (rhBMP-2), 2 or 5 μg of rhBMP-2 was implanted int...
متن کاملDistraction Osteogenesis and Its Challenges in Bone Regeneration
Bone is amongst the very few tissues in the human body that possess intrinsic capacity to heal spontaneously following injury. However, beyond a certain critical size defect, bone cannot heal by itself and outside intervention is required. Numerous techniques are available for the management of these defects, including the gold standard autogenous bone grafts, allografts, bone graft substitutes...
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ژورنال
عنوان ژورنال: Journal of Oral and Maxillofacial Surgery
سال: 2018
ISSN: 0278-2391
DOI: 10.1016/j.joms.2017.11.016